I would like to present some health problems that are common for the Chinese Crested dogs. These problems are not specific to the breed itself and may be quite common for other breeds also. The gene pool for the Chinese Crested is from a very limited stock (see breed history) and everybreeder should have at least the eyes and the patellars of their breeding dogs certified.
Chinese crested dog as it is a miniature breed can suffer from diseases which are common for miniature breeds e.g.
Diseases which are probably conected with hairlessness:
LCPD Research /sadly chinese cresteds were excluded/
Our breed has a disease called Legg Calve Perthes Disease (LCPD). This disease is caused by the disruption of the blood supply to the head of the femur (the round bone which fits into the hip socket). When this happens, the result is death of bone cells and femur head gets deformed. There appears to be an increasing incidence of this disease showing up in Chinese Cresteds. This lead to contact with researcher Alison N. Starr, Ph.D, Assistant Research Professor on Canine Genetics Laboratory at Clemson University.
They are very interested in including the Chinese Crested in the study and this is a big oppertunity for us to identify the mutation causing LCPD and we could have a genetic test in the future (like we have with prcd-PRA).To accomplish this we need your help!!! The minimum blood samples required is 25 affected and 25 unaffected but the more samples they get over all increases the odds of them identifying the gene/s involved in this disease.
PRA Research (non-prcd) and retinophaty
OptiGen®, LLC (USA)
Dr. Simon Petersen-Jones
Short Information in regards to Chinese Crested Dog PRA Research
By Dr. Kristina Narfström January 10, 2010
Since approximately 1.5 years I’ve been engaged in PRA research concerning the Chinese Crested Dog (CCD). The background is that many cases of retinal blinding disease have been observed in CCDs in Sweden. Some of the affected dogs have been blood tested in regards to the prcd mutation, responsible for PRA in a number of dog breeds, and has also been found in CCDs affected by retinal blinding disease (see http://www.optigen.com). We have found that many of the cases observed in Sweden have been negative for this mutation even though they have gone blind with a retinal disease process.
Through examination of a large number of CCDs in Sweden and smaller groups of CCDs in USA, I have found that we are dealing with more than one problem in the breed in regards to retinal disease. First of all, there are a lot of color variations in the breed and this affects also the retinal appearance, causing color changes that may be difficult to differentiate from early stage PRA. Secondly, there appears to be a “new” type of retinal disease in the breed different from classical PRA. The disease is very slowly progressive and some cases lead to severe visual impairment or blindness. The disorder appears to affect the outermost layer of the retina, not only photoreceptors primarily as in classical PRA. Upon eye examination using indirect ophthalmoscopy, the disease has a somewhat different appearance than PRA of the prcd type. I call this “new” type of retinal problem CCD retinopathy. Thirdly, we also see classical PRA in the breed, in dogs that are positive for the prcd mutation.
Through research into the retinal problems of CCDs we will evaluate and study cases that have been diagnosed with PRA or PRA-like disease but that have been blood tested and are negative for the prcd mutation. In collaboration with the crestednetwork.se and the CCD breed club in Sweden, Dr. Tomas Bergstrom and Dr. Leif Andersson, both at the Swedish University of Agricultural Sciences and Uppsala University, and Dr. Gary Johnson and Liz Hansen, both at the University of Missouri, MO, USA, we want to find the gene/mutation for the CCD retinopathy. At the same time the plan is to characterize the disease clinically and using laboratory methods, such as electroretinography (ERG) and morphology (microscopic examination of tissues from affected individuals).
In order for us to succeed we would like to obtain blood samples from CCDs that have been diagnosed with retinal blinding disease/PRA but that have been blood tested and are negative for the prcd mutation. For this, fresh blood can be submitted in purple top vials (EDTA), together with a copy of the latest eye examination certificate issued by a board certified veterinary ophthalmologist, and a copy of the pedigree of the affected dog. Initially we will screen for mutations known to cause PRA in other dog breeds, such as the CORD1 mutation. Then, further molecular genetic research will be performed.
Address for submission of blood in USA:
Animal Molecular Genetics Laboratory, Attention: Liz Hansen
University of Missouri –College of Veterinary Medicine
321 Connaway Hall
Columbia, MO 65211
Phone: 573 884 3712
Thank you for your help!
KRISTINA NARFSTRÖM, DVM, PhD, DipECVO
Professor of Ophthalmology
University of Missouri-Columbia
EP - Epilepsy in Chinese Crested Dogs
Paw Print Genetics (USA)
Epilepsy project at Paw Print Genetics. (update 02.2016)
We have received samples for 201 dogs and extracted
DNA on all of those.
Bern University (Switzerland)
Epilepsy can occur in humans and in many dog breeds. Epilepsy can result from brain damage (e.g. trauma), or genetic mutations. In dogs the hereditary forms of epilepsy are probably very important. We plan to investigate the underlying genetic mechanisms for various forms of epilepsy in different dog breeds. The goal of our research is the development of diagnostic tests, which will allow a reduction of the epilepsy cases by a targeted breeding strategy. For our research we need blood samples from epilepsy affected dogs and their relatives.
|DNA LABORATORIES FOR TESTING YOUR CHINESE CRESTED|
|Other DNA testing labs: http://www.offa.org/dna_labs.html|
|Chinese Crested Health Database||http://www.crestedhealth.net/|
|European Crested DiVision||http://ecd.fullmonty.nl/|
|Chinese Crested Links - Health||http://crestedlinks.2n3055.com/htm/health.html|
|Chinese Crested Health UK||http://liddyleaze.netfirms.com/alldogs.htm|
|UK Chinese Crested Health||http://www.geocities.com/oolagha/crestedhealthUK.html|
|ACCC Health Survey (.pdf)||http://accc.chinesecrestedclub.info/forms/health_survey.pdf|
|ACCC Health Survey (.doc)||http://accc.chinesecrestedclub.info/forms/health_survey.doc|
|OFA Chinese Crested Health Survey||http://www.offa.org/surveys/survey_crested.html|
|Orthopedic Foundation for Animals||http://www2.offa.org/index.html, http://www.offa.org/|
|Veterinary Medical Database||http://www.vmdb.org/|
|Polish Small Animal Veterinary Association (PSAVA)||http://www.pslwmz.org.pl/|
|CERF (Canine Eye Registration Fundation)||http://www.vgl.ucdavis.edu/research/canine/|
|Keratoconjunctivitus Sicca (KCS)/ Dry Eye||http://www.chinesecrested.no/article/health/Keratoconjunctivitus+Sicca+%28KCS%29+or+Dry+Eye|
|Genetic test for prcd-PRA||http://www.optigen.com|
|Canine Genome Project||http://www.vgl.ucdavis.edu/research/canine/|
|Canine Genetic Diseases Network||http://www.caninegeneticdiseases.net/|
|Laboklin - genetic tests (Germany)||http://www.laboklin.de|
|Closed Ear Canal = CEC||
|PNA - Progressive Neuronal Abiotrophy = CMSD - Canine Multiple System Degeneration||http://www.angelfire.com/ia2/kerryblues/pna.html|
|Canine Inherited Disorders Database||Canine Inherited Disorders Database|
|AKC Canine Health Foundation||http://www.akcchf.org/|
|European College of Veterinary Ophthalmologists||http://www.ecvo.org/public/index.htm|
|Home||Copyright © 2004- Katarzyna Zienkiewicz - Rosa Thea Kennel|